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pentobarbital will minimize the level or influence of vinorelbine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.Barbiturates can induce hepatic microsomal enzymes causing greater metabolism and reduced anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon